Preparing you for your SCE in Endocrinology and Diabetes
715 questions
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June 2022 Exam
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Demo Question
A 43-year-old male presented to hospital with acute myocardial infarction. His blood test showed that his total cholesterol was 7.8 mmol/L and his low-density lipoprotein cholesterol (LDL-C) was 13.5 mmol/L.
As per NICE guidelines, at what level of LDL-C, diagnosis of Homozygous familial hypercholesterolaemia should be considered?
If LDL-C concentration greater than 9 mmol/L
If LDL-C concentration greater than 10 mmol/L
If LDL-C concentration greater than 11 mmol/L
If LDL-C concentration greater than 12 mmol/L
If LDL-C concentration greater than 13 mmol/L
Key Learning Point
Consider a clinical diagnosis of homozygous FH in adults with a low-density lipoprotein cholesterol (LDL-C) concentration greater than 13 mmol/l and in children/young people with an LDL-C concentration greater than 11 mmol/l.
Explanation
NICE recommends:
"Healthcare professionals should consider a clinical diagnosis of homozygous FH in adults with a low-density lipoprotein cholesterol (LDL-C) concentration greater than 13 mmol/l and in children/young people with an LDL-C concentration greater than 11 mmol/l. All people with a clinical diagnosis of homozygous FH should be offered referral to a specialist centre.
To confirm a diagnosis of FH, healthcare professionals should undertake two measurements of LDL-C concentration because biological and analytical variability occurs.
Healthcare professionals should be aware that the absence of clinical signs (for example, tendon xanthomata) in adults and children/young people does not exclude a diagnosis of FH."
