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Demo Question
Which of the following may be responsible for a hypokalaemic hypertension?
Bartter's syndrome
Diabetic nephropathy
Liddle's syndrome
Non-classical congenital adrenal hyperplasia
Type IV renal tubular acidosis (RTA)
Key Learning Point
Liddle's syndrome is typically associated with hypokalaemic hypertension and low renin and aldosterone concentrations - the so-called pseudo-hyperaldosteronism.
Explanation
Liddle's syndrome is typically associated with hypokalaemic hypertension and low renin and aldosterone concentrations - the so-called pseudo-hyperaldosteronism.
Bartter's syndrome is associated with hypokalaemia, though hypertension is not a feature.
In type IV RTA, there is a hyporeninaemic hypoaldosteronism, which may also be produced with diabetic nephropathy, hence hyperkalaemia is more typical.
