Choose how you want to revise

Select Questions

Revise with my preferences. Choose your difficulty or recap questions you've found hard.

Mock tests

Test myself against recent exam themes and ones curated by BMJ’s editorial team of doctors.

Group Learning

Play under a username and join friends or others for 10 questions. Move up of the daily leaderboard.

On the go

Download the app for offline access. Make revision easily fit into your schedule.

Select the best subscription for your exam date

Join 200,000+ OnExamination users who have successfully become medical professionals

Revise with quality questions and detailed explanations



Demo Question

 

A 43-year-old male presented to hospital with acute myocardial infarction. His blood test showed that his total cholesterol was 7.8 mmol/L and his low-density lipoprotein cholesterol (LDL-C) was 13.5 mmol/L.

As per NICE guidelines, at what level of LDL-C, diagnosis of Homozygous familial hypercholesterolaemia should be considered?

  If LDL-C concentration greater than 9 mmol/L

  If LDL-C concentration greater than 10 mmol/L

  If LDL-C concentration greater than 11 mmol/L

  If LDL-C concentration greater than 12 mmol/L

  If LDL-C concentration greater than 13 mmol/L



Key Learning Point

 

Consider a clinical diagnosis of homozygous FH in adults with a low-density lipoprotein cholesterol (LDL-C) concentration greater than 13 mmol/l and in children/young people with an LDL-C concentration greater than 11 mmol/l.



Explanation

 

NICE recommends:

Healthcare professionals should consider a clinical diagnosis of homozygous FH in adults with a low-density lipoprotein cholesterol (LDL-C) concentration greater than 13 mmol/l and in children/young people with an LDL-C concentration greater than 11 mmol/l. All people with a clinical diagnosis of homozygous FH should be offered referral to a specialist centre.


To confirm a diagnosis of FH, healthcare professionals should undertake two measurements of LDL-C concentration because biological and analytical variability occurs.

Healthcare professionals should be aware that the absence of clinical signs (for example, tendon xanthomata) in adults and children/young people does not exclude a diagnosis of FH.

Customer Reviews

Based on 2 reviews
100%
(2)
0%
(0)
0%
(0)
0%
(0)
0%
(0)
A
Anonymous
|

|

R
Ramesh Kumar
Fantastic

Perfect for SCE

Smart features to maximise your revision efforts

Daily questions

Keep on track. Set a time that suits you, we will send you a personalised revision question every day.

Revision plans

Turn weaknesses into strengths. Focus on the specialities that will give you the biggest learnings.

Feedback & peer comparison

Indicates how likely you are to pass. Detailed performance graphs show how you’re currently performing and benchmark you against your peers.

Customer Reviews

Based on 2 reviews
100%
(2)
0%
(0)
0%
(0)
0%
(0)
0%
(0)
A
Anonymous
|

|

R
Ramesh Kumar
Fantastic

Perfect for SCE

Save time and focus on the most important questions

High Impact Questions

Maximise your revision time. High Impact Questions instantly delivers you the most important questions, ranked by our clinical tutors and your peers.