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Question of the Day

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A routine ultrasound at 18 weeks' gestation in a diabetic mother reveals a male fetus with an endocardial cushion defect.

Other abnormalities include increased nuchal thickening and a 'double bubble' sign.

Which of the following conditions is most likely to have contributed to this set of findings?

(Please select 1 option)

Congenital syphilis
Marfan's syndrome
Maternal folate deficiency
Maternal use of ACE inhibitor
Trisomy 21

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